An essay on rasmussens encephalitis

Thus when these antibodies were removed by plasma exchange PEX it caused a temporary relief from the seizures but soon the body starts making more antibodies of the type and the seizures start once again.

Treatment Despite the clear involvement of inflammation in its pathogenesis, the response to immunosuppressive therapy is often disappointing.

Finally, there is a relatively stable residual stage with a severe fixed neurological deficit, motor and cognitive problems, and with persisting difficult-to-treat relapsing epilepsy.

After this has been done many times the hemisphere in which sufferers of Ramussen"s encephalitis is present will deteriorate to the point where a hemispherectomy has to be performed. Hanovar, "Rasmussen"s encephalitis in surgery for epilepsy. Neuroimaging is an important step in the evaluation of these patients to help exclude many of the aforementioned diagnoses.

Early in the illness, other causes of focal seizures and status epilepticus need to be considered, including focal or lateralized malformations of cortical development, neoplasms, vascular malformations of the brain, cerebral infarctions, and porencephalic cysts, all of which may cause focal seizures in childhood.

Now a malicious rhythm begins: Causes The exact cause of Rasmussen encephalitis is not known. So if these GluRs were put into the normal blood stream then the immune system would produce antibodies which could then be used in the searching for the glutamate receptors.

Now the help of McNamara and Andrews was enlisted. EPC is characterized by An essay on rasmussens encephalitis rapid, rhythmic succession of contractions and relaxations of a muscle or muscle group myoclonusparticularly of the arms, legs, and face, that may occur An essay on rasmussens encephalitis or in a repetitive, continuous series.

Pathology from autopsy and surgical specimens shows microglial nodules and perivascular mononuclear cell infiltration. The first clue was delivered when Rogers and Gahring were trying to register the distribution of the glutamate receptors using antibodies, that tag on to the receptor itself.

In some very rare cases, the disease can progress to involve the opposite brain hemisphere. The inflammation is caused by the autoimmune process against the GluR.

As of now there are no FDA approved drugs for the sufferers of Ramussen"s encephalitis. A spastic hemiparesis typically develops, and this can become severe. The only problem with this theory is that the rabbits developed seizures without ever being whacked on the head, but that also could be because a rabbit"s brain is not as well insulated as a human"s.

Now imagine a condition where this awesome system turns against the most complex organ in the human body, the brain. Science term papers Disclaimer: This will only cease the seizures temporarily, but they will start again when the body has made more new antibodies.

The first clue was delivered when Rogers and Gahring were trying to register the distribution of the glutamate receptors using antibodies, that tag on to the receptor itself.

The proteins that make up the glutamate receptors GluR are only found inside the blood brain barrier BBB. Serial imaging may show progression of atrophy over time. All the seizures occur where the initial break in the BBB happened due to a blow to the head, explaining why they seizures are confined to just one hemisphere.

This will render the person to mental disintegration where he or she has no more mental capacity and generally to the point of no return, death.

At this point the experiment took a dramatic turn, after receiving a few doses of the protein two of the three rabbits began to twitch, as though they were suffering the pain of an epileptic seizure.

When McNamara and Andrews examined the brain tissue of the rabbits, they saw what seemed to be a familiar inflammatory pattern, clumps of immune cells all around blood vessels. As protective as the BBB is, it can be breached by something like a head injury.

Now the researchers are working on a drug that will block the activity of this particular antibody, but this could lead to further problems. The human immune system is an amazing system that is constantly on the alert protecting us from sicknesses. Normally what happens to an individual is that after he or she is involved in this cycle the only thing that can make for relief is the recurrent plasma exchange.

Thus when these antibodies were removed by plasma exchange PEX it caused a temporary relief from the seizures but soon the body starts making more antibodies of the type and the seizures start once again.

These were not only the right kind of antibodies but, the very antibodies that caused the seizures in people and rabbits. The disorder is rare and affects mostly children or young adults. Deadly as it is, this condition is known as Rasmussen? The meaningful research on Rasmussen"s encephalitis was begun unintentionally by Scott Rogers and Lorise Gahring, two neurologists, who were at the time measuring the distribution of glutamate receptors in the brain.

December 5pp. If one of these GluRs happens to wander into the actual bloodstream, that is outside the BBB, it would be considered an outsider and destroyed immediately. The exact cause of this disorder is not known. In order to test this theory the researchers injected the GluRs into the blood stream of a normal healthy rabbit hoping to produce good results.

Its precise role in management of Rasmussen encephalitis remains to be determined. A healthy brain has its blood capillaries enclosed in the BBB membrane, so such a case as the one mentioned above would not be possible.Rasmussen's Encephalitis Essays: OverRasmussen's Encephalitis Essays, Rasmussen's Encephalitis Term Papers, Rasmussen's Encephalitis Research Paper, Book Reports.

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the brain. Deadly as it is, this condition is known as Rasmussen?s encephalitis.

Rasmussen’s encephalitis: clinical features, pathobiology, and treatment advances

The meaningful research on Rasmussen?s encephalitis was begun (unintentionally) by Scott Rogers and Lorise Gahring, two neurologists, who were at the time measuring the distribution of glutamate receptors in the brain.

Rasmussen encephalitis is a sporadic disease. It has not been associated with any particular environments or populations and cannot be caught from others. [2] Research is underway to help better understand the underlying cause.

Rasmussen's encephalitis is an asymmetric encephalitis that presents with intractable focal seizures, progressive hemiparesis, and unilateral hemispheric atrophy.

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It was first reported in the literature in (Rasmussen et al., ). Rasmussen’s encephalitis is a progressive disease characterised by drug-resistant focal epilepsy, progressive hemiplegia, and cognitive decline, with unihemispheric brain atrophy. The disorder is rare and affects mostly children or young adults.

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An essay on rasmussens encephalitis
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